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Bengals rookie quarterback Andy Dalton completed 25 of 32 passes (78.1%) for 264 yards passing and a touchdown during Cincinnati's 27-17 win over the Indianapolis Colts on Sunday. The performance earned him Cincy Jungle's Game Ball of the Week as well as one of four Pepsi NFL Rookie of the Week nominations. And according to the NFL, he was one of five players considered for the week six Offensive AFC Player of the Week (not just rookie). This is the second time this year Andy Dalton has been nominated (and failed to win) the NFL's weekly award. Cedric Benson, A.J. Green and Jerome Simpson have also received nominations this year.
Pittsburgh running back Rashard Mendenhall won the award after rushing for 146 yards on 23 carries with a touchdown during the Steelers 17-13 win over the Jacksonville Jaguars. Other nominations included New England quarterback Tom Brady (289 yards passing, two touchdowns and two picks), Bills running back Fred Jackson (121 yards rushing and a touchdown) and Ravens running back Ray Rice (161 yards from scrimmage).
The NFL week six winners are:
| AFC Offensive Player of the Week | Rashard Mendenhall | Pittsburgh |
| AFC Defensive Player of the Week | Darrelle Revis | New York (A) |
| AFC Special Teams Player of the Week | Jacoby Ford | Oakland |
| NFC Offensive Player of the Week | Ahmad Bradshaw | New York (N) |
| NFC Defensive Player of the Week | Kurt Coleman | Philadelphia |
| NFC Special Teams Player of the Week | Devin Hester | Chicago |