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Arian Foster, Vernon Davis, Bernard Pierce likely out; Jamaal Charles may play

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The big surprise on the injury front is that of Kansas City Chiefs star Jamaal Charles, whose ankle injury may not be as serious as originally thought.

Chris Humphreys-USA TODAY Sports

There will be several big-name starting running backs on the sidelines when NFL Sunday Week 3 kicks off. The biggest name will be Houston Texans All-Pro Arian Foster.

Now dealing with yet another hamstring issue, Foster isn't expected to play against the New York Giants, according to Ian Rapoport, who reported the news live on NFL Network Gameday Morning. Foster was limited in practice majority of the week with his hamstring injury and this will put the Texans offense leaning on running backs Alfred Blue, Jonathan Grimes and Ronnie Brown.

Ian Rapoport also reports it's "doubtful" that San Francisco 49ers tight end Vernon Davis (ankle, knee) plays Sunday against the Arizona Cardinals. Davis hasn't practiced since leaving last Sunday night's Week 2 loss against the Bears on crutches.

Another starting running back that could be out today is the Baltimore Ravens' Bernard Pierce, who's dealing with a thigh issue. Baltimore signed RB Fitzgerald Toussaint off the practice squad Saturday. If Pierce can't go, Justin Forsett and rookie Lorenzo Taliaferro will carry the load.

The big surprise on the injury front is that of Kansas City Chiefs star Jamaal Charles, whose ankle injury may not be as serious as originally thought.

If Charles doesn't go, expect Kniles Davis to get the bulk of his touches. He did good against the Denver Broncos last week, and could be in for a big day against the Miami Dolphins.